Titlebook: Venom Genomics and Proteomics; P. Gopalakrishnakone,Juan J. Calvete Living reference work 20200th edition

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Shotgun Approaches for Venom Analysis,on allow for sensitive and comprehensive shotgun protein analysis in a high-throughput manner. Combination of shotgun techniques to novel analytical strategies opens interesting possibilities for the implementation of new approaches and methodologies in the frontiers of venom biology. Examples are (

LAPSE

Snake Venom Peptidomics,in the mid-twentieth century, snake venom peptidomics is still in its infancy. Over the last decade, the development of mass spectrometry, transcriptomics, and bioinformatics and the application of these tools to the study of snake venoms have unveiled the proteomes of several species and produced c

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Snake Venom Phospholipase A2: Evolution and Diversity,ionary events in the snakes’ adaptation and survival. The evolution of vPLA.s is inextricably linked to snake phylogeography, ecology, and natural history. It has been shown that both mammalian secretory PLA.s and snake vPLA.s exist as multiple isoforms. The vPLA. genes undergo duplication, accelera

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Snake Venom Proteopeptidomics : What Lies Behind the Curtain,he last 50 years. Furthermore, a deep knowledge of snake venom protein composition is necessary for better understanding the envenomation physiopathology and to contribute to the broadening in the clinical efficacy and range of antivenom therapy. During the past 15 years, several groups have applied

Outspoken

Squamate Reptile Genomics and Evolution,enom toxins. The rapid accumulation of genomic information from squamate reptiles is generating important new context and insights into the biology, the regulation and diversity of venom toxins, and the evolutionary processes that have generated this diversity. It is an exciting time as we discover

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Structure-Function Relationship in Heterodimeric Neurotoxin PLA2s from Viperidae Snakes Inhabiting inae snakes. In contrast to their monomeric counterparts, they have a sophisticated mechanism of action in order to avoid nonspecific binding to “wrong” targets and to increase the efficiency of the pharmacological attack. ncHdPLA.s consist of a toxic and enzymatically active basic PLA. and an acidi

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Structure-Function Relationship of Modular Domains of P-III Class Snake Venom Metalloproteinases,orrhagic activity of venoms and may also interfere with the hemostatic system. Phylogenetically, SVMPs are most closely related to the mammalian ADAM (a disintegrin and metalloproteinase) protein family, a major class of membrane-bound sheddases. Together with ADAMs and the related ADAMTS (ADAM with

Mast-Cell

The Platypus: A Venomous Mammal,nom through spurs located on their hind legs. Venom delivery is believed to provide individuals with an advantage over conspecifics throughout the breeding season. This paper reviews the current literature on platypus venom, focusing primarily on recent advances which have been made since the sequen

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