Titlebook: Vasopressin and Oxytocin; Molecular, Cellular, Hans H. Zingg,Charles W. Bourque,Daniel G. Bichet Book 1998 The Editor(s) (if applicable) an

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Mechanisms of Neuroendocrine Cell Excitabilitymals and released into their blood, eventually to have profound hormonal actions on peripheral tissues. In the rat both OT and VP neurons fire slowly and irregularly under conditions of low demand for peptide release, but natural or artificial depolarizing stimuli result in differential patterns of

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Properties of the Transient K+ Current in Acutely Isolated Supraoptic Neurons from Adult Ratons acutely isolated from the adult rat. In the presence of tetrodotoxin, depolarizing steps applied from a negative holding potential evoked a rapidly activating and inactivating outward current followed by a slowly activating and sustained outward current. The I. was unaffected by tetraethylammoni

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Local Glutamatergic and GABAergic Synaptic Circuits and Metabotropic Glutamate Receptors in the Hypozation of the hypothalamic neurons. The projected synaptic inputs as well as the local synaptic organization of the cells play a crucial role in generating patterned electrical activity and synchronizing activity among individual cells of a given population of hypothalamic neurons. The majority of t

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Regulation of Vasopressin Release by Ionotropic Glutamate Receptor Agonistss in the supraoptic nuclei(1–4). A role for EAA regulation of vasopressin (VP) release is suggested by the ability of the non-specific EAA antagonist, kynureic acid, to inhibit osmotically stimulated VP release from explants of the hypothalamo-neurohypophyseal system (HNS)(5). In addition, both N-me

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Role of ,-Methyl-D-Aspartate (NMDA) Receptors in Vasopressin and Oxytocin Responses to Emotional Sti) and after anxiety-producing novel environmental stimuli (2, 4). The NMDA subtype of glutamate receptor is essential for long-term potentiation of excitatory synaptic transmission in the hippocampus and, thereby, has been postulated to play a crucial role in learning and memory. Behavioural experim

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Electrophysiological Studies of Oxytocin Neurons in Organotypic Slice Cultures recordings of identified neurons show that these cultured oxytocin cells exhibit basal electrical properties closely similar to those of magnocellular cells recorded . and in acute . preparations from adult animals. The cultures also include GABAergic and glutamatergic neurons making connections wi

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Inhibitory Actions of Nociceptin (Orphanin FQ) on Rat Supraoptic Nucleus Oxytocin and Vasopressin Neein coupled receptor family was identified.. This orphan receptor, now named opioid receptor-like 1, ORL-1. weakly binds opioids and the opioid antagonist naloxone.; it is expressed in brain, notably in the supraoptic nucleus (SON;.). Soon after identification of the ORL-1 receptor, an endogenous he