Titlebook: Vasodilators in Chronic Heart Failure; H. Just,W.-D. Bussmann Book 1983 Springer-Verlag Berlin Heidelberg 1983 Dilatation.Failure.circulat

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Functional and Metabolic Consequences of Chronic Alterations in Preload and Afterload in the Hypertrhypertrophy provides a basic mechanism that permits the heart to maintain normal cardiac pump function despite abnormal pressure, stress, or volume load (5–8, 13). However, progression of cardiac hypertrophy is a significant precursor of cardiac dilatation and failure and of coronary insufficiency.

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The Sympathetic Nervous System in Chronic Heart Failure and Its Response to Vasodilator Therapysensors that trigger this reflex adjustment are the arterial baroreceptors. Other sensors may contribute, such as mechanoreceptors at the venoatrial junctions, which, when stretched, enhance the sympathetic outflow to the sinus node, although sympathetic outflow to the kidneys is reduced. The increa

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The Renin-Angiotensin-Aldosterone System in Congestive Heart Failureete sodium and lack the ability to maintain normal sodium balance. During recent years, it has been shown that renin, via angiotensin II, plays an important role in blood pressure homeostasis and in various forms of hypertensive diseases. It has also become apparent that it participates in the vasoc

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Endogenous Catecholamines Under Chronic Vasodilator Treatmente endogenous neurotransmitter noradrenaline augments heart rate and contractility of the failing heart. Since the cardiac muscle fibers are hypersensitive to endogenous or exogenous catecholamines in heart failure, these hormones seem to be essential in restoring left ventricular function. However,

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Effects of Hydralazine and Isosorbide Dinitrate on Vasoconstrictor Mechanisms in Patients with Heart (1). Because the elevation of peripheral resistance may further depress left ventricular function, vasodilators have been used to counteract this vasoconstriction and to improve cardiac performance (2–4). This study examines the effects of isosorbide dinitrate and/or hydralazine on the activity of

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Promises and Disappointments of Vasodilator Treatment of Chronic Heart Failureecome apparent with the increasing application of vasodilators in the treatment of patients with chronic heart failure. The exquisite implicity of the concept that reduction of the pressure against which the left ventricle has to pump would rejuvenate its performance is immensely attractive but sadl

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Nitrates in Chronic Heart Failurey edema, left heart failure during the acute phase of myocardial infarction, papillary muscle syndrome or rupture of the interventricular septum, hypertensive crisis concomitant with heart failure, and certain types of cardiogenic shock. Isosorbide dinitrate and nitroglycerin have been investigated

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The Long-Term Effects of Dihydralazine and Hydralazine on Intractable Cardiac Failureur own clinical studies (38 patients treated with dihydralazine) and a review of the literature. Their short-term effects are well known but there is less information available on their long-term effects (2, 8). It is generally accepted that the pharmacological effects of the two commercially availa

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