Titlebook: Vascular Morphogenesis in the Female Reproductive System; Hellmut G. Augustin,Peter A. W. Rogers,Stephen K. Book 2001 Springer Science+Bu

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Dendritic-Cells

The Role of Angiogenesis in Breast Cancer Progressionat support this viewpoint were first gained in patients with carcinoma of the breast (Weidner et al, 1991), and confirmatory data have subsequently been obtained in studies conducted in breast and many other solid tumors (see Chapter 4). Additionally, the discovery of various proangiogenic and antia

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Oncogenes, Anti-Oncogenes, and Genetic Regulators of Vascular Developmentc lesions that alter the function and regulation of oncogenes, tumor-suppressors, and modifier genes. A key stage of both tissue development and tumor progression is the recruitment of a vascular network.

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Introduction

Growth Factors During Ovarian Angiogenesision of cells with a low mitotic activity (Denekamp, 1984; Hudlická, 1984). This observation is not surprising, because physiologic angiogenesis is usually associated with tissue growth or repair, and most normal adult tissues are relatively stable (Hudlická, 1984; Klagsbrun and D’Amore, 1991).

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Vascular Endothelial Growth Factor: A Key Regulator of Physiologic Angiogenesisnd reproductive functions in the adult (Folkman, 1995). Angiogenesis is also implicated in the pathogenesis of a variety of disorders, including proliferative retinopathies, age-related macular degeneration, tumors, rheumatoid arthritis, and psoriasis (Garner, 1994; Folkman, 1995).

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Angiogenesis, Vascular Imaging, and Therapeutic Approaches in Ovarian Tumorsng neovascularization may be similar between physiologic and tumor-associated angiogenesis (Kohn and Liotta, 1995), angiogenesis has a very different purpose in the context of malignant and nonmalignant ovarian neoplasms. Physiologic angiogenesis supplies nutrients necessary for normal cyclical ovar