Titlebook: Vascular Growth Factors and Angiogenesis; Lena Claesson-Welsh Book 1999 The Editor(s) (if applicable) and The Author(s), under exclusive l

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Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PlGF),989; . et al. 1990), VEGF-B (. et al. 1996), VEGF-C (. et al. 1996) and .-induced growth factor (FIGF) (. et al. 1996) are members of a family of structurally related growth factors. These factors are all dimeric glycoproteins and share a number of biochemical and functional features (for review, se

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Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors,, been recognised as the major growth factor relatively specific for endothelial cells (reviewed in . and .-. 1997). VEGF is a dimeric glycoprotein, closely related to placenta growth factor (PIGF). Both VEGF and PIGF are distantly related in structure to the platelet-derived growth factors A and B

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Structure and Function of Vascular Endothelial Growth Factor Receptor-1 and -2, and malignant transformation. The endothelial cell-specific growth factors, denoted vascular endothelial growth factors/vascular permeability factors (VEGF/VPF), constitute a growing family of factors that bind to at least three different receptor-type tyrosine kinases (Fig. 1). A wealth of data in

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Vascular Endothelial Growth Factor Receptor-3,eceptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine kinase), KDR/Flk-1 (Kinase insert-domain containing receptor or fetal-liver kinase-1) and Flt4, re

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Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvasculease the permeability of microvessels to plasma and plasma proteins (. et al. 1979a,b). Using plastic-embedded, light microscopic section and, subsequent, immunohistochemistry, we noted that transplantable tumors growing in guinea pigs and rodents exhibit substantial deposits of fibrin in their stro

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The Angiopoietins: Yin and Yang in Angiogenesis,phological organization in the context of their surrounding tissues (. 1991, 1995). Vascular development is generally classified into two successive phases. The first, known as vasculogenesis, refers to the process whereby newly differentiated endothelial cells spontaneously coassemble into tubules

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Vascular Endothelial Growth Factor Receptor-3,mmunoglobulin homology domains in the extracellular domain, and a tyrosine kinase intracellular domain split by a kinase insert sequence (for recent reviews, see . and D’. 1996; . and D’. 1996; . and . 1995; . and ., 1998, .-., this book).