Titlebook: Validating Neuro-Computational Models of Neurological and Psychiatric Disorders; Basabdatta Sen Bhattacharya,Fahmida N. Chowdhury Book 201

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Discovery and Validation of Biomarkers Based on Computational Models of Normal and Pathological Hipcant effects on frequency. A biophysically realistic model of the electrical activity of the hippocampus, an early target of Alzheimer’s disease is also manipulated on a synaptic and cellular level to simulate biochemical effects of amyloid-. accumulation. This can help elucidate a mechanism of age-

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Limpid

,Computational Models of Closed–Loop Deep Brain Stimulation, being applied to the parkinsonian network by examining both quantitative measures of neurons in the basal ganglia and the relay error of thalamocortical (TC) neurons. Our computational results show that closed–loop MDFS significantly diminish TC relay error by breaking the bursting pattern and desy

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HUSH

Multilevel Computational Modelling in Epilepsy: Classical Studies and Recent Advances, as we believe this “systems approach” to epilepsy research is from where the most significant new advances, particularly with regards model validation, will occur. We highlight some of the key studies, as well as emphasising more recent breakthroughs to provide a useful entry point into this rapidl

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Assault

,Modelling Cortical and Thalamocortical Synaptic Loss and Compensation Mechanisms in Alzheimer’s Discortical network model which oscillates within the alpha frequency band (8–13 Hz) as recorded in the wakeful relaxed state with closed eyes. The thalamocortical network model (TC-model) includes different types of cortical excitatory and inhibitory neurons recurrently connected to thalamic and retic

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Toward Networks from Spikes,sh at most hundreds of spiking neurons while cultures comprise thousands of neurons. Even as the number of electrodes increases with gains in technology, it is important to understand how much information about the network connectivity can be discovered with sparse spatial sampling. We describe an a

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Epileptogenic Networks: Applying Network Analysis Techniques to Human Seizure Activity, from a multi-electrode array (MEA) implanted in human cortex. The results are used to define epileptogenic networks, which can be validated against the visually identifiable development and propagation of the seizure. We then characterize each network and quantify the degree of similarity between n

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2197-1900 ok serves as a step towards a systematic approach to validation of neuro-computational models used for studying brain diseases and should be useful for all neuro-computational modellers..978-3-319-37136-8978-3-319-20037-8Series ISSN 2197-1900 Series E-ISSN 2197-1919