Titlebook: Vaccines against Allergies; Rudolf Valenta,Robert L. Coffman Book 2011 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Passive Immunization with Allergen-Specific Antibodies,llergic patients treated by allergen-specific immunotherapy. Several studies suggest that allergen-specific IgG antibodies induced by vaccination with allergens block mast cell and basophil degranulation, IgE-facilitated allergen presentation to T cells and IgE production. The availability of recomb

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Cell-Based Therapy in Allergy, effective therapeutic or preventive approaches inducing robust tolerance toward allergens remains an unmet goal. Several experimental tolerance approaches have been described. The therapeutic use of regulatory T cells (Tregs) and the establishment of molecular chimerism are two cell-based strategie

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Induction of Allergen-Specific Tolerance via Mucosal Routes,ered together with the combined use of adjuvants/vector systems and recombinant allergens or peptide fragments. Herein, we review the current status in the use of mucosal routes (i.e., sublingual, oral, intranasal) for allergen-specific immunotherapy, as well as the latest understanding with respect to underlying mechanisms of action.

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