Titlebook: Vaccines; Recent Trends and Pr Gregory Gregoriadis,Anthony C. Allison,George Post Book 1991 Plenum Press, New York 1991 AIDS.Antigen.develo

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Escape Mechanisms of Viruses from Immune Responses and Their Relevance to Vaccine Design,ties of the viral genome and the abilities of the host’s immune system to mount efficient immune responses aimed at eradicating the virus from the body. It is likely that during evolution the virus genomes which have survived have done so because of either versatility permitting antigenic variation,

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Use of Syntex Adjuvant Formulation to Enhance Immune Responses to Viral Antigens,he development of better adjuvant formulations so that both humoral and cell-mediated immunity are enhanced. We have been interested in the adjuvant formulation area of vaccine development for some time, and believe that the Syntex Adjuvant Formulation (SAF) has a number of advantages that will make

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Influenza Vaccines and the Wyeth-Ayerst Experience with Syntex Adjuvant, over 20,000 people each year in the United States (Katz, 1985). In addition, the illness has a substantial economic impact. Schoenbaum (1987) estimated that the total direct cost of influenza (health care cost) exceeds $1 billion per year in the U.S., with the actual cost (including lost productivi

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Effects of Added Cytokines on Immune Responses and Memory,e to antigens. In recent years a new group of such molecules has been defined and partially characterised. These are non-antigen specific molecules which affect specific immune responses in various ways — the cytokines. The increasing availability of cytokines in purified form, as recombinant protei

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The Assessment and Use of Adjuvants,sed to allow a detailed experimental appraisal of the recommendations but researchers have questioned some of the tests. In addition, vaccinologists interested in the practical uses of adjuvants must face the problems of the proposed phasing out of mineral oils.

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Efficient Anti-Idiotypic Immunization with Homologous, Virus Neutralizing Monoclonal Antibodies Conin serum (Tiel et al, 1986). In that assay, the spike proteins of SFV, either E. or E., can be detected in infected L cell monolayers with a horse radish peroxidase (HRPO-) labeled anti-E. or anti-E. specific monoclonal antibody (MA). Preincubation of the virus inoculum with SFV neutralizing serum r

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Protein Conformation Affects the Efficacy of Pertussis Vaccines,s published on the cloning and expression of genes from a variety of human and animal pathogens, as yet only the hepatitis B recombinant vaccine has been successfully introduced for human immunization and there are not many other promising candidates foreseen in the near future. The general finding