Titlebook: Vaccine Delivery Technology; Methods and Protocol Blaine A. Pfeifer,Andrew Hill Book 2021 Springer Science+Business Media, LLC, part of Spr

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Computational Antigen Discovery for Eukaryotic Pathogens Using ,rtunately, there is no program as yet that can predict whether a protein will induce a protective immune response to a pathogen. Nonetheless, predicting those pathogen proteins most likely from those least likely to induce an immune response is feasible when collectively using predicted protein char

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Bioreactor-Based Antigen Production Process Using the Baculovirus Expression Vector System, baculoviral DNA (also called bacmid) for cultivating .-9 cells and producing a baculovirus stock from the recombinant bacmid and for producing a protein-based vaccine with the BEVS in a stirred tank reactor.

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High-Throughput Process Development for the Chromatographic Purification of Viral Antigens,purities. There is a multitude of resins available based on different modalities (such as charge, hydrophobicity, and affinity) to provide a spectrum of approaches to meet the separation challenges of the diverse products. The challenge of developing viral antigen purification processes is addressed

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Production of Zika Virus Virus-Like Particles,ZIKV consists of a structural protein outer shell surrounding a nucleocapsid. Virus-like particles (VLP) consist of the outer structural protein shell, but without the nucleocapsid, and are hence noninfectious. VLP, however, are structurally equivalent to the native virus and thus present a similar

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Upstream and Downstream Processes for Viral Nanoplexes as Vaccines,ents, raises the need for fast and efficient production processes. In general, these processes comprise upstream and downstream processing. For the upstream process, efficiency is mainly characterized by robustly achieving high titer yields, while reducing process times and costs with regard to the

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Whole-Cell Vaccine Preparation: Options and Perspectives, caused the near eradication of many critical diseases and has had an everlasting impact on public health at a relatively low cost. Most of the vaccines developed today are based on techniques which were developed a long time ago. In the beginning, vaccines were prepared from tissue fluids obtained