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Titlebook: Vaccine Adjuvants; Methods and Protocol Christopher B. Fox Book 2017 Springer Science+Business Media New York 2017 Human vaccines.In silico

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发表于 2025-3-21 19:49:44 | 显示全部楼层 |阅读模式
书目名称Vaccine Adjuvants
副标题Methods and Protocol
编辑Christopher B. Fox
视频video
概述Includes cutting-edge methods and protocols in the field of vaccine adjuvant research.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from
丛书名称Methods in Molecular Biology
图书封面Titlebook: Vaccine Adjuvants; Methods and Protocol Christopher B. Fox Book 2017 Springer Science+Business Media New York 2017 Human vaccines.In silico
描述This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved. Beginning with an overview and a case study, the book then delves into .in silico. design, chemical synthesis, biosynthesis, and/or purification from natural raw materials of specific adjuvant molecules, adjuvant formulation approaches, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, as well as the biological characterization of vaccine adjuvant activity, including in vitro and in vivo approaches, to measure innate and adaptive immune responses. Written in the highly successful .Methods in Molecular Biology. format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Practical and authoritative, .Vaccine Adjuvants: Methods and Protocols. aims to facilitate vaccine adjuvant product development efforts, making them more accessible, manufacturable, and better character
出版日期Book 2017
关键词Human vaccines; In silico design; Adjuvant formulation; Chemical synthesis; Stressed stability; Manufactu
版次1
doihttps://doi.org/10.1007/978-1-4939-6445-1
isbn_softcover978-1-4939-8202-8
isbn_ebook978-1-4939-6445-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media New York 2017
The information of publication is updating

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书目名称Vaccine Adjuvants读者反馈学科排名




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Development of the CpG Adjuvant 1018: A Case Study,decades of use, it has become clear that there is a need for alternatives where alum-based adjuvants are suboptimal. Oligonucleotides containing unmethylated CpG sequences represent one alternative as they are potent stimulators of the vertebrate innate immune system through activation of Toll-like
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Syntheses of Human TLR8-Specific Small-Molecule Agonists,s evokes a distinct cytokine profile which favors the development of type 1 helper T cells. Focused exploration of structure-activity relationships in the imidazoquinolines has led to the identification of several novel human TLR8-specific agonists. The synthetic procedures for best-in-class analogu
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QS-21 Adjuvant: Laboratory-Scale Purification Method and Formulation Into Liposomes,nses in a variety of preclinical and clinical studies [1]. Its purification from the natural source is a lengthy and difficult process. The commercially available saponin mixture Quil-A. is a fraction of the bark extract containing a variety of saponins, including QS-21. In order to facilitate acces
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Purification of an Immunoadjuvant Saponin Fraction from , Leaves by Reversed-Phase Silica Gel Chromines is of interest due to their capacity to stimulate both humoral and cellular responses. The congener species . has saponins with chemical similarities and adjuvant activity comparable to that of . fraction Quil-A., with additional advantages of showing lower toxicity and reduced hemolytic activi
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Biosynthetic Approaches to Squalene Production: The Case of Yeast,ditional natural resources of squalene are limited, alternatives for the production of squalene on industrial scale have been intensively explored during past years. The yeast . represents an attractive option due to elaborated techniques of genetic and metabolic engineering that can be applied to i
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