| 书目名称 | Uptake and Trafficking of Protein Toxins |
| 编辑 | Holger Barth |
| 视频video | |
| 概述 | Provides new insights into the development of tailored transport systems for the targeted drug delivery into mammalian cells.Reviews the key recent research on the role of cellular receptors, toxin po |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | .This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of .Clostridium botulinum. neurotoxins, .Clostridium botulinum. C3 toxin, .Clostridium difficile. toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin. In brief, specific binding/transport (B) subunits deliver the enzyme (A) subunits into the cytosol, where the latter modify their substrates, producing cytotoxic effects and the characteristic toxin-associated diseases. Key mechanisms for the transport of the A subunits from endosomes into the cytosol and the role of trans-membrane pores formed by the B subunits and host cell chaperones for this process are reviewed. The book’s closing chapters focus on compounds which inhibit the transport of the A subunits from endosomes into the cytosol and therefore might lead to novel therapeutic strategies for toxin-associated diseases. These substances include pharmacological inhibitors of the host cell chaperones involved, as well as mu |
| 出版日期 | Book 2017 |
| 关键词 | Bordetella pertussis; Botulinum neurotoxins; Clostridium difficile; Clostridium perfringens toxin; Anthr |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-58893-3 |
| isbn_softcover | 978-3-319-86502-7 |
| isbn_ebook | 978-3-319-58893-3Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 17:24:10
