Titlebook: Unraveling the Exposome; A Practical View Sonia Dagnino,Anthony Macherone Book 2019 Springer International Publishing AG, part of Springer

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Epigenetics and the Exposomeosures such as tobacco smoke, air pollution, and metal exposures in population-based studies. On the other hand, deviant DNA methylation is a major epigenetic mechanism of epigenetic silencing in a wide range of human diseases including cancers. Epigenetic modifications might play a prominent role i

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Metabonomicshe size and diversity of the chemical space that metabolites occupy means that measuring the human metabolome via serum, urine, or other biofluids or tissues represents a huge analytical challenge, addressed by the application of high-resolution platforms, typically incorporating liquid- and/or gas-

neutrophils

Transcriptomics within the Exposome Paradigme ubiquitous mixtures. Although environmental exposures occur to mixtures of chemicals rather than to individual agents, most of the toxic effects of air pollutants are ascribed to single chemicals. There is a growing feeling in both the scientific and regulatory communities, however, that there is

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The Food Exposomes. Several 100 food-derived compounds can be simultaneously measured as part of the human exposome in very small human biospecimens collected in large populations. These approaches and their implementation in dietary-wide association studies are reviewed. This could significantly advance nutritional

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Ingenuity

From the Outside In: Integrating External Exposures into the Exposome Conceptsuch as social and built environment as well as behavioral factors. The grand challenge lies in how to provide a comprehensive and rigorous characterization of the external environment on the exposome scale. This chapter will discuss

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Exposome-Wide Association Studies: A Data-Driven Approach for Searching for Exposures Associated wite association study” (EWAS). First, we will describe the philosophy behind such a study, including transparency and mitigation of the chances for selection biases. Second, we will describe how to mitigate chances of type 1 error and investigate the possibility of true signals in a sea of possible fa

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EXPOsOMICs: Meet-in-the-Middle and Network Perturbations of cancer as intermediate steps between exposure to carcinogens and the cancer phenotype, according to the “meet-in-the-middle” concept. We use examples derived from the study of mutational spectra in tumours and benzo(a)pyrene and bisphenol A as model carcinogens. We suggest conceptualising the d