Titlebook: Unhappiness, Sadness and ‘Depression‘; Antidepressants and Tullio Giraldi Book 2017 The Editor(s) (if applicable) and The Author(s) 2017 d

唠叨

Early Treatments,s due to the suggestion provided by the therapist and the suggestibility of the patient. The existence of the placebo effect was then shown for the first time, and the need to take it into account during the evaluation of medical treatments was recognised.

技术

The Rise of Effective Treatments,rs. At the same time, the need appeared for clinical trials capable of objectively evaluating the efficacy and safety of new drugs, clarifying the contribution provided by the placebo effect: the randomised controlled trial became the “gold standard”, opening the way to newer and safer medicines and antidepressants

Encumber

Assessing Efficacy,ntries; after the Second World War, evidence of efficacy was also required for medicinal products. Evidence-based medicine thus provided safe and effective medicines, but did this happen to antidepressants?

勉励

The Effectiveness of Antidepressants Today,h sales of 22 billion dollars. Subsequent serious investigations revealed that the clinical trials given to the regulatory agencies used unreal and irrelevant criteria of effectiveness; in the real world, few patients responded to the treatment at all, and for mild depression the response was equal to that of a placebo

judiciousness

A Matter of Chemistry,as Prozac the theory was refocused specifically on serotonin. Yet no direct evidence has ever been provided regarding in vivo conditions in real patients. Additionally, clinical evidence such as the latency of the response and the lack of activity in about one-third of patients treated remains unexplained.

reject

踉跄

Introduction,ion: A Global Crisis’. The WHO called depression “a global public health concern”, with 350 million sufferers, and with one in 20 people reporting an episode of depression in the previous year; by 2030 the WHO expects it to become the main contributor to the global burden of disease. Depression is c

saturated-fat

Melancholy and Depression,alence of black bile, was associated with the low mood condition thus called “melancholia”. This view also led to the development of treatments such as emetics and cathartics, and of widespread bloodletting. Radical evolutions occurred with the foundation of modern psychiatry and the classification

anarchist

Nebulizer