Titlebook: Ubiquitin and the Biology of the Cell; Jan-Michael Peters,J. Robin Harris,Daniel Finley Book 1998 Springer Science+Business Media New York

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Ubiquitination of the p53 Tumor Suppressor,ne, 1979). Nearly 10 years later it was discovered that p53 is a tumor suppressor and that mutations in the p53 gene are very frequently associated with many types of human cancers (Levine ., 1991; Vogelstein and Kinzler, 1992). As our understanding of the biochemical functions and regulation of thi

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Cell Cycle Control by Ubiquitin-Dependent Proteolysis,curate segregation of replicated chromosomes. The cell cycle control machinery regulates progression from one phase of the chromosome cycle to the next, ensuring that DNA replication (S phase) alternates with chromosome segregation (mitosis) to maintain a constant ploidy. In most cells, growth is co

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Ubiquitination of Integral Membrane Proteins and Proteins in the Secretory Pathway,ena as DNA repair, organelle biogenesis, and protein turnover. Best understood among these is the role of the ubiquitin system in targeting cytoplasmic proteins for proteolysis by the 26 S proteasome complex (reviewed in Chapter 6). Although most of the substrates for the ubiquitin conjugation syste

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Polyubiquitin Chains,n comprises a polymeric ubiquitin chain, and that the 26 S proteasome harbors specific components that recognize this chain with high affinity. However, the molecular aspects of chain recognition are only beginning to be understood, and the proteasomal components that bind polyubiquitin chains remain largely uncharacterized.

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depreciate

Cell Cycle Control by Ubiquitin-Dependent Proteolysis,efore be regulated. In contrast, early embryonic division occurs in the absence of cell growth, so that the cell cycle consists solely of rapidly alternating S and M phases. Despite these distinct physiologies, a common biochemical machinery regulates cell division in all eukaryotic cells.

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Ubiquitination of Integral Membrane Proteins and Proteins in the Secretory Pathway,ion and trafficking of proteins within the central vacuolar system. By central vacuolar system, I refer collectively to the compartments of the secretory and endocytic/lysosomal pathways including the endoplasmic reticulum, Golgi apparatus, plasma membrane, lysosomes, and the various transitional compartments and transport vesicles.

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The Ubiquitin System,which discoveries were made; and (3) to point out some challenges that workers in the ubiquitin field, and those who may stumble into it from other areas, may face in the future. These different subjects are discussed in light of my personal experience with the ubiquitin proteolytic system.