| 书目名称 | Tumor Angiogenesis |
| 副标题 | Basic Mechanisms and |
| 编辑 | Dieter Marmé (Professor),Norbert Fusenig (Professo |
| 视频video | |
| 概述 | Written by internationally renowned experts.Development of novel drugs (e.g. Avastin) makes new therapeutic strategies in the treatment of cancer possible.Includes supplementary material: |
| 图书封面 |  |
| 描述 | Preface Tumor development and progression occur as a result of cumulative acquisition of genetic alterations affecting oncogenes and tumor suppressor genes. As a consequence of these alterations the arising tumor gains some fatal properties such as increased cell proliferation and decreased apoptosis, resulting in a net accumulation of tra- formed cells. Once a critical volume is achieved, lack of oxygen and nutrients limits further growth. To overcome this obstacle, the tumor cells initiate a program focused on the formation of new blood vessels within the host tissue. This process is termed tumor angiogenesis and contributes to the progression of most solid tumors and the formation of metastases. Since its discovery more than 30 years ago by Dr. Judah Folkman, tumor angiog- esis has been proposed as an ideal target for novel tumor therapies. Today the first anti-angiogenic compounds are available for the treatment of patients but their s- cess in the clinic is rather limited when given as monotherapies. This is in contrast to many preclinical results which revealed a much higher efficacy of these therapeutics in appropriate animal models. The reasons for this discrepancy are mani |
| 出版日期 | Book 2008 |
| 关键词 | angiogenesis; cancer; cancer therapy; cancer treatment; chemotherapy; clinical research; drug; drug develop |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-540-33177-3 |
| isbn_softcover | 978-3-662-51798-7 |
| isbn_ebook | 978-3-540-33177-3 |
| copyright | Springer-Verlag Berlin Heidelberg 2008 |
发表于 2025-3-21 18:42:05
