| 书目名称 | Transglutaminases | | 副标题 | Multiple Functional | | 编辑 | Kiyotaka Hitomi,Soichi Kojima,Laszlo Fesus | | 视频video | | | 概述 | Provides detailed descriptions of basic knowledge and recent findings on the structure, mechanism of action, physiological significance, and pathological implications of transglutaminases.Provides hin | | 图书封面 |  | | 描述 | .This book presents basic and extensive information on the physiological and pathological significance of the protein-modifying enzymes, transglutaminases, which are involved in multiple biological events by catalyzing a unique and important posttranslational modification reaction, cross-linking of proteins, and interacting with a large number of proteins inside and outside of cells. Although several of their essential physiological roles have been revealed, many unknown and so far not fully understood functions have remained. In humans, there are eight active isozymes having distinct tissue and subcellular distribution patterns with different substrates and physiological roles. Accordingly, aberrant regulation of the enzyme reactions or expression may lead to or has been implicated in various pathologies including neurodegeneration, fibrosis, cancer, inflammation, celiac disease, and hemostasis disorders.To provide those who are new to the field with basic knowledge and recent information on transglutaminase structures and reactions, the mechanism by which transglutaminases modify substrate proteins and their contributions to multiple biological phenomena as well as disease phenot | | 出版日期 | Book 2015 | | 关键词 | Subcellular localization; Substrates and inhibitors; Transglutaminase KO mice; Celiac disease; Neurologi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-4-431-55825-5 | | isbn_softcover | 978-4-431-56703-5 | | isbn_ebook | 978-4-431-55825-5 | | copyright | Springer Japan 2015 |
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发表于 2025-3-21 18:38:00
