| 书目名称 | Transcriptional Control of Cell Growth |
| 副标题 | The E2F Gene Family |
| 编辑 | Peggy J. Farnham (Associate Professor of Oncology) |
| 视频video | |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through out the lifespan of all animals. An important control point in this balance occurs in the G, phase of the cell cycle. On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state. Alterations in the mechanisms that nor mally control this decision can lead to cancer, cell death, or loss of differentiated cellular phenotypes. The identification of the E2F gene family of transcription factors has allowed a more complete understanding of how the cell maintains an appropri ate proliferative state. This volume provides an up-to-date ac count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Either partner can be one of several different transcription factors; E2Fl, E2F2, E2F3, E2F4, or E2F5 can heterodimerize with either DPl or DP2. Cellular promoters whose E2F sites mediate a link between transcription |
| 出版日期 | Book 1996 |
| 关键词 | DNA; cell; cell cycle; cell nucleus; gene; gene regulation; growth; influence; protein; protein structure; pro |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-79910-5 |
| isbn_softcover | 978-3-642-79912-9 |
| isbn_ebook | 978-3-642-79910-5Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 18:54:40
