| 书目名称 | Towards Dual and Targeted Cancer Therapy with Novel Phthalocyanine-based Photosensitizers |
| 编辑 | Janet T F Lau |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D. thesis by the The Chinese University of Hong Kong, People‘s Republic of China.Explores different approaches to develop phthalocyanine-based photosensitizers toward du |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | Janet Lau‘s thesis describes her studies into the use of phthalocyanine-based photosensitizers in combined chemo- and photodynamic therapy (PDT) and targeted PDT. In order to carry out this study, Lau uses several approaches: conjugation with a chemotherapeutic oxaliplatin derivative, use of a polyamine ligand 2 with a view to targeting the polyamine transporters over-expressed in tumor cells, and employment of a quencher that can inhibit their photodynamic activity but can still be removed under a tumor-associated environment such as low pH and high thiol concentration. This thesis reports dual activatable photosensitizers for the first time. Overall the studies included are original and the effects have been well demonstrated at the cellular level. The work in this thesis is of much current interest and importance, and can pave foundation for further developments. Accordingly, part of the results has been published in prestigious scientific journals. |
| 出版日期 | Book 2013 |
| 关键词 | Activatable Photosensitizer; Dual Therapy; Oxaliplatin Derivative; Photodynamic Therapy; Phthalocyanine; |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-00708-3 |
| isbn_softcover | 978-3-319-03316-7 |
| isbn_ebook | 978-3-319-00708-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer International Publishing Switzerland 2013 |
发表于 2025-3-21 17:19:40
