| 书目名称 | Total Synthesis of Natural Products with Antimicrobial Activity |
| 编辑 | Andrew Giltrap |
| 视频video | |
| 概述 | Focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery.Describes the total synthesis of two |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the .Pseudomonas aeruginosa. biofilms that are responsible for significant mortality among cystic fibrosis patients.. |
| 出版日期 | Book 2018 |
| 关键词 | Non-Ribosomal Peptides (NRPs); Total Synthesis; Teixobactin; Skyllamycins A-C; Proteinogenic Amino Acids |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-10-8806-3 |
| isbn_softcover | 978-981-13-4245-5 |
| isbn_ebook | 978-981-10-8806-3Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Singapore Pte Ltd. 2018 |
发表于 2025-3-21 20:05:25
