| 书目名称 | Total Synthesis of Indole Alkaloids |
| 副标题 | Based on Direct Cons |
| 编辑 | Junpei Matsuoka |
| 视频video | http://file.papertrans.cn/927/926635/926635.mp4 |
| 概述 | Nominated as an outstanding Ph.D. thesis by Kyoto University.Provides novel strategies for the construction of pyrrolocarbazole core structures.Explains the design and development of divergent synthes |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | This book explores efficient syntheses of indole alkaloids based on gold-catalyzed cascade cyclizations, presenting two strategies for total synthesis of these natural products based on gold-catalyzed reactions of conjugated diyne or ynamide. .The book first describes the total and formal synthesis of dictyodendrins A–F based on direct construction of the pyrrolo[2,3-c]carbazole core using the gold-catalyzed annulation of azido-diynes and protected pyrrole. This synthetic strategy features late-stage functionalization of the pyrrolo[2,3-c]carbazole scaffold at several positions and allows diverse access to dictyodendrins and their derivatives. Secondly, the book discusses the formal synthesis of vindorosine based on the pyrrolo[2,3-d]carbazole construction using the gold-catalyzed cascade cyclization of ynamide. Importantly, the reaction using a chiral gold complex provides the optically active pyrrolo[2,3-d]carbazole. This strategy facilitates the rapid construction of the pyrrolocarbazole core structure of aspidosperma and related alkaloids, including vindorosine. .These methodologies can accelerate the medicinal application of pyrrolocarbazole-type alkaloids and related compound |
| 出版日期 | Book 2020 |
| 关键词 | Gold Catalysis; Total Synthesis of Dictyodendrin; Pyrrolocarbazole; Cascade Reaction; Indole Alkaloid; Na |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-15-8652-1 |
| isbn_softcover | 978-981-15-8654-5 |
| isbn_ebook | 978-981-15-8652-1Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor |
|Archiver|手机版|小黑屋|
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