| 书目名称 | Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes a |
| 编辑 | Shinsuke Inuki |
| 视频video | |
| 概述 | Total synthesis of the bioactive natural products, pachastrissamine, lysergic acid, lysergol and isolysergol, by palladium-catalyzed domino cyclization of allenes and related compounds is investigated |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure. |
| 出版日期 | Book 2012 |
| 关键词 | allene cyclization; bioactive natural products; ergot alkaloid; functionalized heterocycles; naural prod |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-4-431-54043-4 |
| isbn_softcover | 978-4-431-56110-1 |
| isbn_ebook | 978-4-431-54043-4Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer 2012 |
发表于 2025-3-21 19:02:57
