| 书目名称 | Therapeutic Antibodies | | 副标题 | Methods and Protocol | | 编辑 | Antony S. Dimitrov | | 视频video | | | 概述 | Outlines the current state and future trends for therapeutic antibodies.Provides complete guidelines to discover and develop therapeutic antibodies, from antigen production to animal studies.Presents | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to use theactiveingredientinthebloodofvaccinated(orimmunized)animalsorhumansfor the treatment of diseases came a century later. It was made possible by a series of discoveries,suchastherealizationthattheserumfromanimalsimmunizedwithtoxins, for example, diphtheria toxin or viruses, is an effective therapeutic against the disease causedbythesameagentinhumans. Inthe1880s,vonBehringdevelopedanantitoxin (anti-body) that did not kill the bacteria but neutralized the bacterial toxin. The first Nobel Prize in Medicine (1901) was given to him for the discovery of the serum therapy. Acenturylater,22monoclonalantibodies(mAbs)areapprovedbytheUnited States Food and Drug Administration (FDA) for clinical use, and hundreds are in clinicaltrialsforthetreatmentofvariousdiseasesincludingcancers,immunedisorders, and infections. The revenues from the top-five therapeutic antibod | | 出版日期 | Book 2009 | | 关键词 | Antibody discovery; Antibody engineering; Antibody libraries; Antibody preclinical development; Antigen; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-554-1 | | isbn_softcover | 978-1-62703-869-0 | | isbn_ebook | 978-1-59745-554-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 2009 |
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发表于 2025-3-21 18:02:16
