| 书目名称 | The Systemic Effects of Advanced Cancer | | 副标题 | A Textbook on Cancer | | 编辑 | Swarnali Acharyya | | 视频video | | | 概述 | Discusses the systemic effects of metastatic disease and their impact on the host.Highlights cachexia, a debilitating systemic consequence of advanced cancer, associated with poor patient survival.Sum | | 图书封面 |  | | 描述 | .This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1...Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and | | 出版日期 | Textbook 2022 | | 关键词 | systemic cancer effects; cachexia; cancer metabolism; Muscle wasting; tumour microenvironment; cancer met | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-09518-4 | | isbn_softcover | 978-3-031-09789-8 | | isbn_ebook | 978-3-031-09518-4 | | copyright | Springer Nature Switzerland AG 2022 |
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发表于 2025-3-21 19:33:01
