| 书目名称 | The Sodium-Hydrogen Exchanger | | 副标题 | From Molecule to its | | 编辑 | Morris Karmazyn,Metin Avkiran,Larry Fliegel | | 视频video | | | 概述 | Includes a wide spectrum of topics dealing with sodium-hydrogen exchange ranging from molecular to clinical.Covers established and emerging concepts related to sodium hydrogen exchange including newly | | 图书封面 |  | | 描述 | I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on "Cell Surface and Malignancy". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I su | | 出版日期 | Book 2003 | | 关键词 | Activation; Colon; Escherichia coli; genes; regulation; transcription | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4615-0427-6 | | isbn_softcover | 978-1-4613-5071-2 | | isbn_ebook | 978-1-4615-0427-6 | | copyright | Springer Science+Business Media New York 2003 |
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发表于 2025-3-21 17:19:18
