| 书目名称 | The Pulmonary Neuroepithelial Body Microenvironment | | 副标题 | A Multifunctional Un | | 编辑 | Inge Brouns,Line Verckist,Dirk Adriaensen | | 视频video | | | 概述 | Focuses on sensory nerves in the airways.Highlights the multidisciplinary approach to study NEBs.Explores NEBs potential as stem cell niche | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | .This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis..Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lume | | 出版日期 | Book 2021 | | 关键词 | neuroendocrine cell; pulmonary disease; NEB; airway epithelium; pulmonary sensory receptors; stem cell ni | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-65817-5 | | isbn_softcover | 978-3-030-65816-8 | | isbn_ebook | 978-3-030-65817-5Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 17:56:40
