| 书目名称 | The Neuroendocrine Leydig Cells and their Stem Cell Progenitors, the Pericytes | | 编辑 | Michail S. Davidoff,Ralf Middendorff,Adolf F. Hols | | 视频video | http://file.papertrans.cn/915/914711/914711.mp4 | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | cells, and the testicular localization of the intermediate filament protein nestin, known to be expressed in neural stem cells, by our group was the first step to define mural cells (pericytes and vascular smooth muscle cells) of the testis microvascu- ture as the stem/progenitor cells of the adult Leydig cells. In summary, we were able to demonstrate specific proliferation of vascular progenitors and their subsequent transdifferentiation into steroidogenic Leydig cells, which – in addition – rapidly acquire neuronal and glial properties. Since both newly developed fetal and adult Leydig cell populations show the same features, a common origin of both popu- tions seems likely. Pericytes are distributed throughout the body, and there is convincing evidence for their stem/progenitor cell properties in diverse organs. Under appropriate (locally defined) conditions these pericytes, which reside in the vascular stem cell niche as dormant stem cells, become activated, proliferate, migrate and differentiate towards different somatic cell types of the body. Since most mesenchymal stem/ progenitor cell types exhibit essential similarity to pericytes and certain mesenchymal stem cells repres | | 出版日期 | Book 2009 | | 关键词 | Sertoli cells; aorta-gonad-mesonephros region; cell; development; hormone; influence; microvascular mural | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-00513-8 | | isbn_softcover | 978-3-642-00512-1 | | isbn_ebook | 978-3-642-00513-8Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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