| 书目名称 | The Medicinal Chemistry of Glucocorticoid Receptor Modulators |
| 编辑 | Adrian Hobson |
| 视频video | |
| 概述 | Outlines the development of glucocorticoid receptor modulators from 1950 to 2022.Shows how prodrugs and metabolic inactivation are applied to drug discovery.Presents Antibody-Drug Conjugates for immun |
| 丛书名称 | SpringerBriefs in Molecular Science |
| 图书封面 |  |
| 描述 | This book covers the design and development of glucocorticoid receptor modulators (GRM) from cortisol to antibody-drug conjugate payloads over the last 70 years. The author starts with an introduction to the background of glucocorticoid receptor modulators as potential therapeutic modalities. This is followed by seven chapters in which he collates and discusses the medicinal chemistry journey of GRMs, reviewing topics such as cortisol-based glucocorticoids, the different approaches that have been pursued to enable chronic dosing of GRM compounds by inactivation in plasma and the liver, the application of prodrugs to GRMs, selective GRMs, targeted delivery of GRMs using polymers and nanoparticles, and rational drug design approaches applied in the development of GRMs. Particular attention is given to the development of glucocorticoid receptor modulators as immunology antibody-drug conjugate payloads. In the book’s final chapter, the author critiques the medicinal chemistry progress madesince the discovery of cortisone and the promise of the latest antibody-drug conjugates that release a GRM payload. In this book, readers will also find an overview of the X-ray structures of glucocor |
| 出版日期 | Book 2023 |
| 关键词 | Antibody Drug Conjugates; Glucocorticoid Receptor Modulators (GRM); Prodrugs; Metabolic Inactivation; Ta |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-031-28732-9 |
| isbn_softcover | 978-3-031-28731-2 |
| isbn_ebook | 978-3-031-28732-9Series ISSN 2191-5407 Series E-ISSN 2191-5415 |
| issn_series | 2191-5407 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 17:33:35
