| 书目名称 | The M2 Macrophage | | 编辑 | Tamás Röszer | | 视频video | | | 概述 | Provides a comprehensive summary of M2 macrophage functions.Fills an important gap in the literature on leukocyte biology.Can be used as a textbook or reference guide | | 丛书名称 | Progress in Inflammation Research | | 图书封面 |  | | 描述 | .Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key ques | | 出版日期 | Book 2020 | | 关键词 | macrophage; immunity; metabolism; tissue homeostasis; M1/M2 model of polarization; infectious diseases | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-030-50480-9 | | isbn_softcover | 978-3-030-50482-3 | | isbn_ebook | 978-3-030-50480-9Series ISSN 1422-7746 Series E-ISSN 2296-4525 | | issn_series | 1422-7746 | | copyright | Springer Nature Switzerland AG 2020 |
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发表于 2025-3-21 16:14:57
