| 书目名称 | The Local Cardiac Renin-Angiotensin Aldosterone System | | 编辑 | Edward D. Frohlich,Richard N. Re | | 视频video | | | 概述 | Includes supplementary material: | | 图书封面 |  | | 描述 | How exciting it is to see a field so well established as the ren- angiotensin system continue to grow and mature. Originally, following the original identification of renin by Tigerstedt and Bergman over 100 years ago, workers in this area spent years attempting to establish its role in experimental and renal hypertension. The early work by Goldblatt, in 1934, demonstrated that the placement of a clip around a renal artery was clearly related to the subsequent development of hypertension. However, it wasn‘t until the simultaneous finding by two different geographically separated teams, Page, et al, in the United States and Braun-Menendez, et al, in Argentina that the peptide angiotensin was identified. Thus, the rate-limiting enzyme renin was released from the kidney and catalyzed a biochemical cascade which was eventually shown to produce the elevated arterial pressure. Subsequently, many workers contributed to the elucidation of the concept and sequence of angiotensin I1 generation. Thus, the enzyme renin acted upon its protein substrate, produced in the liver, to liberate the decapeptide angiotensin I which, upon circulating through the pulmonary circulation, finally produced th | | 出版日期 | Conference proceedings 20061st edition | | 关键词 | arterial pressure; cardiovascular; circulation; heart; hypertension | | 版次 | 1 | | doi | https://doi.org/10.1007/0-387-27826-5 | | isbn_ebook | 978-0-387-27826-1 | | copyright | Springer-Verlag US 2006 |
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发表于 2025-3-21 18:44:42
