| 书目名称 | The Future of Predictive Safety Evaluation | | 副标题 | In Two Volumes Volum | | 编辑 | A. N. Worden,D. V. Parke,J. Marks | | 视频video | | | 图书封面 |  | | 描述 | Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on accoun | | 出版日期 | Book 1987 | | 关键词 | cancer; clinical trial; drug; drug safety; neurotoxicity; research; toxicity; toxicology | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-009-3201-2 | | isbn_softcover | 978-94-010-7936-5 | | isbn_ebook | 978-94-009-3201-2 | | copyright | MTP Press Limited 1987 |
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发表于 2025-3-21 20:08:19
