| 书目名称 | The Enigma of Slow Viruses | | 副标题 | Facts and Artefacts | | 编辑 | Pawel P. Liberski | | 视频video | | | 丛书名称 | Archives of Virology. Supplementa | | 图书封面 |  | | 描述 | Scrapie, a naturally occurring neurodegenerative disease of sheep and sometimes goats, is a prototypic disease for the whole group of the subacute spongiform virus encephalopathies. Kuru was the first human disease of this type to be discovered in 1957 by Gajdusek and Zigas, and its discovery opened the whole field in the human biomedical sciences by the very realization of the fact that viruses may induce disease months or even decades after infections, and that these slow virus diseases are more compatible with classical degenerations of the nervous system than with inflammatory disorders of the brain. More than a quarter ofa century since discovery of Kuru, and more than half acentury following the first transmission of scrapie, the very nature of the infectious virus remains unknown.This comprehensive review covers all aspects of slow unconventional virus infections known today. It includes numerous historical data, biochemistry and molecular biology of the prion protein and its gene, the role of genetics and mutations within PrP gene, spreading and targeting of the virus, biochemistry and neurochemistry of the alterations of different neurotransmitter system and neuropathology | | 出版日期 | Book 1993 | | 关键词 | Nervous System; biochemistry; brain; diseases; gene; genetics; immunology; infection; infections; molecular b | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7091-9270-2 | | isbn_softcover | 978-3-211-82427-6 | | isbn_ebook | 978-3-7091-9270-2Series ISSN 0939-1983 | | issn_series | 0939-1983 | | copyright | Springer-Verlag/Wien 1993 |
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发表于 2025-3-21 18:55:39
