| 书目名称 | The DNA Damage Response: Implications on Cancer Formation and Treatment | | 编辑 | Kum Kum Khanna,Yosef Shiloh | | 视频video | | | 概述 | Offers up-to-date and comprehensive review of latest advances in DNA damage sensing, signalling and repair field.Describes current bottlenecks and future directions.Discusses the relationship between | | 图书封面 |  | | 描述 | The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and fu | | 出版日期 | Book 2009 | | 关键词 | BRCA; Chromosom; DNA; DNA Damage; Telomere; aging; genes | | 版次 | 1 | | doi | https://doi.org/10.1007/978-90-481-2561-6 | | isbn_softcover | 978-94-007-7995-2 | | isbn_ebook | 978-90-481-2561-6 | | copyright | Springer Science+Business Media B.V. 2009 |
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发表于 2025-3-21 18:19:24
