| 书目名称 | The Cerebral Perivascular Cells | | 编辑 | D. N. Angelov,M. Walther,O. Guntinas-Lichius | | 视频video | | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells. | | 出版日期 | Book 1998 | | 关键词 | Nervous System; Neuronal degeneration; antigen presentation; central nervous system; microglia; migration | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-72251-6 | | isbn_softcover | 978-3-540-64638-9 | | isbn_ebook | 978-3-642-72251-6Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
The information of publication is updating
|
|
发表于 2025-3-21 18:08:18
