| 书目名称 | Th 17 Cells: Role in Inflammation and Autoimmune Disease | | 编辑 | Valérie Quesniaux,Bernhard Ryffel,Franco Padova | | 视频video | http://file.papertrans.cn/904/903765/903765.mp4 | | 概述 | A topical volume describing in detail the Th17 cell population.Several new therapeutic targets are discussed in this context.International authorship.Includes supplementary material: | | 丛书名称 | Progress in Inflammation Research | | 图书封面 |  | | 描述 | The IL-17 cytokines represent a novel family of cytokines, which defines a new effector T cell, the Th17 cell, and extend the Th1-Th2 paradigm. Th17 cells in part co-express at least IL-17A and IL-17F, IL-21 and IL-22. IL-17 A/F are produced by T cells ( and ), iNKT cells, and possibly neutrophils, dendritic cells and Paneth cells. The regulation of IL-17 family member’s expression, and the identification of effector mechanisms are an area of intense current research. Recognized regulators of IL-17A expression include the nuclear receptor ROR t, proinflammatory cyt- ines such as IL-1, IL-6 with TGF- , IL-21, IL-23 IL-25 in the absence of IFN- and IL-4, which are discussed. Recent data suggest that IL-17A may have a dual fu- tion – pro-inflammatory and anti-inflammatory- suggesting that IL-17A may also contribute to terminate inflammation. Further, a reciprocal regulation of Th17 and regulatory T cells including the role of retinoic acid and TGF- is discussed. The discovery that patients with rheumatoid arthritis, allergic disorders, psor- sis and inflammatory bowel disease express IL-17A generated interest in the medical community and instigated a flurry of experimental research on | | 出版日期 | Book 20091st edition | | 关键词 | Arthritis; Autoimmune diseases; Immunity; Promoter; allergic disorders; asthma; autoimmune disease; immune | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-7643-8681-8 | | isbn_ebook | 978-3-7643-8681-8Series ISSN 1422-7746 Series E-ISSN 2296-4525 | | issn_series | 1422-7746 | | copyright | Birkhäuser Basel 2009 |
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