| 书目名称 | Telomeres and Telomerase in Aging, Disease, and Cancer | | 副标题 | Molecular Mechanisms | | 编辑 | K. Lenhard Rudolph | | 视频video | | | 概述 | Provides an in depth review of our current knowledge on the role of telomeres and telomerase in ageing, disease and cancer.Special focus is on adult stem cells.Describes future directions in research | | 图书封面 |  | | 描述 | Twenty-five years after the disclosure of the telomeric DNA sequence and 22 years after the discovery of telomerase, it has become clear that telomeres and telomerase influence disease of human ageing including cancer. This book summarizes our current knowledge on the role of telomeres and telomerase in ageing, regeneration, and cancer with a special focus on ageing stem cells. Moreover, the book reviews current ef forts to target telomeres and telomerase for anticancer treatment or reg- erative therapies. 1. 1 Ageing The molecular analysis of ageing is an emerging research field that will have great impact on patients care, lifestyle, and on disease prevention in the human population worldwide. Major molecular mechanisms that influence the ageing process include (1) the accumulation of molecular damage affecting DNA and p- teins, (2) alterations in gene expression, including alterations in checkpoint responses, metabolic pathways, and developmental pathways, and (3) the decline in adult stem cell function. All these mechanisms lead to a decrease in organ main- nance and function, thus representing a major factor limiting the quality of life d- ing ageing. Moreover, the accumulatio | | 出版日期 | Book 2008 | | 关键词 | Ageing; DNA; Telomere; aging; apoptosis; cancer; cell; cell lines; development; influence; molecular mechanism | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-73709-4 | | isbn_softcover | 978-3-642-09288-6 | | isbn_ebook | 978-3-540-73709-4 | | copyright | Springer-Verlag Berlin Heidelberg 2008 |
The information of publication is updating
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer影响因子(影响力)
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer影响因子(影响力)学科排名
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer网络公开度
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer网络公开度学科排名
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer被引频次
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer被引频次学科排名
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer年度引用
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer年度引用学科排名
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer读者反馈
书目名称Telomeres and Telomerase in Aging, Disease, and Cancer读者反馈学科排名
|
|
|
发表于 2025-3-21 16:27:44
