| 书目名称 | Tau Biology | | 编辑 | Akihiko Takashima,Benjamin Wolozin,Luc Buee | | 视频video | | | 概述 | Presents expert opinions and up-to-date studies on tau.Provides new insights into the tau molecule and tauopathies.Offers inspiration for development of effective therapies | | 丛书名称 | Advances in Experimental Medicine and Biology | | 图书封面 |  | | 描述 | .This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer‘s disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. .Tau Biology. will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging b | | 出版日期 | Book 2019 | | 关键词 | Tauopathies; Neurofibrillary tangle; NFT; Neuronal death; Brain aging; Therapy; Diagnosis | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-32-9358-8 | | isbn_softcover | 978-981-32-9360-1 | | isbn_ebook | 978-981-32-9358-8Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | Springer Nature Singapore Pte Ltd. 2019 |
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发表于 2025-3-21 19:05:33
