| 书目名称 | Targeting the DNA Damage Response for Anti-Cancer Therapy |
| 编辑 | John Pollard,Nicola Curtin |
| 视频video | |
| 概述 | Reviews the basic science of the DDR, its role in tumorigenesis, in dictating response to DNA damaging drugs and the emerging crop of clinical agents that target the DDR for potential anti-cancer bene |
| 丛书名称 | Cancer Drug Discovery and Development |
| 图书封面 |  |
| 描述 | .Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It has also been shown that defects in this network, predominantly within the ATM mediated signaling pathway, are commonly observed in cancers and may be a primary event during tumorigenesis. Such defects may promote a genomically unstable environment, facilitating the persistence of mutations, any of which may provide a growth or survival advantage to the developing tumor. In addition, these somatic defects provide opportunities to exploit a reliance on remaining repair pathways for survival, a process which has been termed synthetic lethality. As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents thatmay have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR. .In this book we will review a series of important topics that are of great inter |
| 出版日期 | Book 2018 |
| 关键词 | DNA repair; ATR; ATM; DNA-PK; CHK; Synthetic lethality; Ionising radiation; Chemotherapy resistance; gene th |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-319-75836-7 |
| isbn_softcover | 978-3-030-09336-5 |
| isbn_ebook | 978-3-319-75836-7Series ISSN 2196-9906 Series E-ISSN 2196-9914 |
| issn_series | 2196-9906 |
| copyright | Springer International Publishing AG, part of Springer Nature 2018 |
发表于 2025-3-21 16:18:32
