| 书目名称 | Targeted Drug Strategies for Cancer and Inflammation | | 编辑 | Ann L. Jackman,Christopher P. Leamon | | 视频video | | | 概述 | Comprehensive focus on the folate receptor and its exploitation for targeted therapy and diagnostic imaging.Describes the boundaries between what’s considered to be “molecular targeted” versus convent | | 图书封面 |  | | 描述 | .Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a | | 出版日期 | Book 2011 | | 关键词 | De Novo Purine Nucleotide Biosynthesis; RFC-SLC19A1; Thymidylate Synthase Inhibitors; folate receptors; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4419-8417-3 | | isbn_softcover | 978-1-4899-8886-7 | | isbn_ebook | 978-1-4419-8417-3 | | copyright | Springer Science+Business Media, LLC 2011 |
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发表于 2025-3-21 17:46:31
