| 书目名称 | T Cell Activation by CD1 and Lipid Antigens | | 编辑 | D. Branch Moody | | 视频video | | | 概述 | Includes supplementary material: | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | .For decades, T cells were thought to solely respond to protein-derived antigens. However, the discovery of the CD1 antigen presenting system shows how antigen presenting cells can display lipid antigens to T cells. Crystal structures show that CD1 proteins accomplish this function by inserting lipids into a hydrophobic groove on the distal surface of the protein, forming CD1-lipid complexes that act as ligands for T cell receptors. CD1-reactive T cells with conserved (NK T cells) or diverse T cell receptors possess cytokine secretion and other effector mechanisms that influence many aspects of immune response. There is increasing evidence that the CD1 system has been conserved throughout mammalian evolution and is capable of presenting structurally diverse diacyglycerol, sphingolipid, polyisoprenol and lipopeptide antigens. These features of CD1 antigen presentation systems now point to a new and expanded view of the natural function of ab T cells, which involves surveillance of both the protein and lipid components of target cells. Further, cellular systems that were previously considered to have functions in lipid metabolism can now be studied in context of their immunological f | | 出版日期 | Book 2007 | | 关键词 | Antigen; NKT cells; T cell; antigen presentation; autoimmune disease; autoimmunity; bacteria; bacterial lip | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-540-69511-0 | | isbn_softcover | 978-3-642-08906-0 | | isbn_ebook | 978-3-540-69511-0Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
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发表于 2025-3-21 18:01:53
