Titlebook: Systems Medicine; Ulf Schmitz,Olaf Wolkenhauer Book 2016 Springer Science+Business Media New York 2016 bioinformatic.chronic pulmonary di

Costume

Systems Medicine in Oncology: Signaling Network Modeling and New-Generation Decision-Support Systemsociations of targeted inhibitors against distinct altered signaling-network pathways. This goal implies a sufficiently in-depth molecular diagnosis of the personal cancer of a given patient. A sufficiently robust and extended dynamic modeling will suggest rational combinations of the abovementioned

Mingle

Neurological Diseases from a Systems Medicine Point of Viewvels of physiological granularity. The individual components, their interactions, and dynamics involved in brain development and function can be represented as molecular, cellular, or functional networks, where diseases are perturbations of networks. These networks can become a useful research tool

Hamper

Computational Modeling of Human Metabolism and Its Application to Systems Biomedicine the complexity of the data presents challenges in interpretation, and new avenues are needed to address the complexity of both diseases and data. Constraint-based modeling is one formalism applied in systems biology. It relies on a genome-scale reconstruction that captures extensive biochemical kno

Misgiving

From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidising and implementing personalized medicine in clinical practice and research. Here we review and critically assess these opportunities and challenges using our work on COPD as a case study. We find that there are significant unresolved biomedical challenges in how to unravel complex multifactorial c

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CRANK

RNA Systems Biology for Cancer: From Diagnosis to Therapympact on clinical practice. This chapter is to elaborate on the state of the art in RNA systems biology, including a review and perspective on clinical applications toward an integrative RNA systems medicine approach. The focus is on the role of ncRNAs in cancer.

Obloquy

Neurological Diseases from a Systems Medicine Point of Viewworks specific for neurological disorders describing disease-related pathology on different scales: the molecular, cellular, and brain level. We also briefly discuss cross-scale network analysis as a necessary integrator of these scales.

Complement