Titlebook: Systems Biology of Free Radicals and Antioxidants; Ismail Laher Reference work 2014 Springer-Verlag Berlin Heidelberg 2014 RNS.ROS.Systems

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Reactive Oxygen Species and Apoptosisate of a cell plays a major role in the regulation of apoptosis in response to any external or internal stimuli. ROS can mediate apoptosis by regulating the expression of various pro-apoptotic proteins such as caspases or anti-apoptotic proteins such as B cell lymphoma-2 (Bcl-2) and cellular FLICE-i

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Exploring the Effect of Redox Enzyme Modulation on the Biology of Mouse Aging mouse models available to test whether redox regulation is a significant factor in the aging process. In general, these data suggest that mammalian aging may be regulated in part by cellular redox state and support further investigation to address whether modulation of redox state can significantly

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Pathophysiological Roles of Reactive Oxygen and Nitrogen Speciesthe mitochondria where ROS superoxides are produced as a by-product of normal oxidative phophorylation; excess superoxide leaking into the cytoplasm can be converted into further ROS, whereas reactivity with NO generates peroxynitrite and further downstream nitrogen species. Here we review the main

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Mitochondrial Superoxide Flashes – From Signaling to Diseasestatic ROS”). In particular, superoxide flash incidence provides a digital readout to gauge glucose- and insulin-stimulated mitochondrial metabolism in live animals, and a novel biomarker of the oxidative stress in hyperosmotic stress, ischemia-reperfusion injury, and neurodegenerative diseases. Suc

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Structural and Metabolic Determinants of Mitochondrial Superoxide and its Detection Methodsendogenous oxaloacetate, which is the subject to phenotypic variations. Complex III-mediated O.. production normally is small but has been implicated in responses to hypoxia and inhibition of complex IV by NO. Mitochondrial SOD2 catalyzes the dismutation of O.. into neutral hydrogen peroxide (H.O.),