Titlebook: Systemic Lupus Erythematosus; Peter A. Miescher Book 1995 Springer-Verlag Berlin Heidelberg 1995 Erythematosus.antibody.antigen.cytokine.c

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Introduction,followed by the discovery of a multitude of related immune phenomena. Thus, the false-positive VDR reaction opened the door to additional antibodies leading to the concept of the anti-phospholipid syndrome. The demonstration of anti-nuclear antibodies led to the discovery of a cascade of antibodies

ZEST

Mechanisms of genetic control of murine systemic lupus erythematosus,ng the incidence, onset and nature of SLE. The involvement of genetic factors in SLE was initially suggested by the fact that there is a familial tendency for SLE. Since a number of different immunopathological manifestations are found in members of the same family, it is likely that the expression

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The role of cytokines in the immunopathogenesis of lupus, [175]. Increasing evidence indicates a critical role for T cells, particularly CD4. cells, in driving B cell hyperactivity. For example, work in mice has shown that actions which inhibit T cell function or deplete T cells, particularly CD4. T cells, improve disease outcome [65, 146, 160, 207]. Many

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The cytokine network in the pathogenesis of systemic lupus erythematosus and possible therapeutic iterized by multisystem organ involvement and autoantibodies against nuclear, cytoplasmic, and cell surface antigens. The mechanisms responsible for the breakdown of tolerance against these self antigens are unknown. Abnormalities of T cells, B cells and antigen-presenting cells result in immune dysr

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Antiphospholipid antibodies and the antiphospholipid syndrome,ELISA test [40], the lupus anticoagulant test [108], and standard tests for syphilis [47]. Currently, there are questions raised by some investigators as to whether these tests truly detect antibodies specific for phospholipids [75, 110], and this issue will be addressed in this review.

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Lupus pregnancies and neonatal lupus,t have permitted patients with SLE to live longer and healthier lives. New clinical research has also described the role that some autoantibodies associated with SLE have on fetal well-being. As a result, many women with SLE or SLE-like disease now attempt pregnancy, and obstetricians, perinatologis