书目名称 | Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products |
编辑 | Kimberley Jade Powell |
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概述 | Nominated as an outstanding Ph.D. thesis by the University of Nottingham, UK.Includes a concise review of electrocyclizations in natural product synthesis.Presents a multidisciplinary approach to the |
丛书名称 | Springer Theses |
图书封面 |  |
描述 | .This thesis addresses fundamental scientific questions such as:.How are complex natural products synthesized in vivo?.Can we replicate these conditions in a laboratory environment?.What is the biological function of such secondary metabolites?.What are the biological origins of chirality?.These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs – the tridachiahydropyrones..The work has achieved:.Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques.The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies.The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques.The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.. |
出版日期 | Book 2016 |
关键词 | Asymmetric electrocyclisation; Biomimetic electrocyclisation; Biomimetic synthesis; Cyanation of vinyl |
版次 | 1 |
doi | https://doi.org/10.1007/978-3-319-22069-7 |
isbn_softcover | 978-3-319-36981-5 |
isbn_ebook | 978-3-319-22069-7Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
issn_series | 2190-5053 |
copyright | Springer International Publishing Switzerland 2016 |