Titlebook: Synthesis of Heterocyclic Compounds; A. L. Mndzhoian Book 1959 Springer-Verlag US 1959 Alkaloid.alkaloids.biology.chemistry.cyclic compoun

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2-Methylfuran (Sylvan),ranching from a high point on the neck; 63 g (0.5 mole) of 5-methyl-2-furoic acid (see p. 33), m.p. 108–109°, was placed in the flask. The mouth of the flask was closed with a stopper carrying a long glass rod B, which was used for clearing the neck from 5-methyl-2-furoic acid sublimate. The side tu

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,-Propylfurfuryl Alcohol, introduced into a 500-ml three-necked round-bottomed flask fitted with mercury-sealed stirrer, dropping funnel, and reflux condenser protected by a calcium chloride tube. A solution of 32 g (0.26 mole) of freshly distilled propyl bromide in 100 ml of dry ether was added dropwise from the dropping f

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Furan,lmost to the bottom of the flask. The mouth of the flask is closed with a rubber bung through which passes the vertical tube C, 15 cm in length and 1.8–2.0 cm in diameter. The upper end of the tube C is closed with a rubber stopper, which carries a long glass rod D; this is used for pushing sublimed

花束

Methyl 5-(Chloromethyl)-2-Furoate, avoid resinification, the flask was cooled with water so as to prevent the temperature from rising above 24–26°. The reaction lasted about two hours; the end of the reaction was indicated by the complete dissolution of the para-formaldehyde: the spontaneous evolution of heat gradually stopped, and the mixture became light yellow in color.

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独特性

,-Phenylfurfuryl Alcohol,til dissolution of the magnesium was substantially complete. The contents of the flask were then cooled with ice and salt and were stirred continuously for 40–50 minutes while a solution of 27.3 g (0.27 mole) of freshly distilled 2-furaldehyde in 150 ml of dry ether was added.

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Methyl 5-Benzyl-2-Furoate, and cooled with ice water for two hours while 40 g (0.3 mole) of anhydrous aluminum chloride was added in small portions. When the vigorous reaction ceased, the mixture was heated in a water bath (temperature of bath 80–85°) for 4–5 hours (see Notes).

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of investigation in this field is due largely to the ever increasing practical importance of heterocyclic com­ pounds. The present stage in the development of organic chemistry and closely allied branches of biology is characterized by extensive investigation of physiologically active substances en

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