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Titlebook: Symposium in Immunology III; Humoral Immunodefici Martha M. Eibl,Christoph Huber,Ulrich Wahn Conference proceedings 1994 Springer-Verlag Be

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B Cell Development in the Mouse: Scenarios for Defects Expressed in the B Cell Lineageolink and Melchers 1991, 1993a, b; Melchers 1993 and references therein). This presentation, given as an introduction to normal B cell development in relation to immunodeficiencies and autoimmune diseases, summarizes the major conclusions for normal B cell development reached in these reviews. It gi
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Factors and Receptors Involved in the Selection of B Lymphocytes Responding to T-Dependent Antigenlow affinity antibodies of the immunoglobulin (Ig)M class and a secondary response where antibodies are of higher affinity and have switched to the use of downstream heavy chain genes. The so-called affinity maturation of TD responses has been attributed to a preference for preserving the better-fit
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The Use of Targeted Mutations in ES Cells to Create Novel Immunodeficient Mouse Models lymphocyte differentiation occurs in fetal liver and adult bone marrow through a well-characterized pathway which includes the ordered assembly of immunoglobulin (Ig) heavy and light chain variable region genes followed by the expression of the assembled Ig chains (Alt et al. 1987, 1992). Likewise,
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