Titlebook: Suppression and Regulation of Immune Responses; Methods and Protocol Maria Cristina Cuturi,Ignacio Anegon Book 2016 Springer Science+Busine

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Standardization, Evaluation, and Area-Under-Curve Analysis of Human and Murine Treg Suppressive Funcanging from autoimmunity to allograft rejection and tumor growth. Reliable identification of human Tregs remains a persistent problem due to a lack of specific markers. The most definitive Treg characterization currently involves combined assessment of phenotypic, epigenetic and functional parameter

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Characterization and Immunoregulatory Properties of Innate Pro-B-Cell Progenitorsammatory cytokine IL-10 or exhibiting killing properties through Fas ligand (Fas-L) or granzyme B-induced cell death. We herein describe the characterization as well as the cellular and molecular mechanisms mediating the suppressive properties of bone marrow immature innate pro-B cell progenitors th

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Generation and Characterization of Mouse Regulatory Macrophagesation. Several types of lymphoid and myeloid cells origin have been generated in vitro and tested in animal models. Their efficacy to decrease pharmacological treatment has successfully been established. Macrophages play an important role in physiological and pathological processes. They represent a

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Autoimmune Diabetes: An Overview of Experimental Models and Novel Therapeutics autoreactive CD4. and CD8. T lymphocytes. The use of animal models of T1D was instrumental for deciphering the steps of the autoimmune process leading to T1D. The non-obese diabetic (NOD) mouse and the bio-breeding (BB) rat spontaneously develop the disease similar to the human pathology in terms o

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Recent Advances in the Treatment of Immune-Mediated Inflammatory Diseasesargeted biological therapies. This paper focuses on new developments in the treatment of IMIDs. In particular, we discuss how different ways of targeting the same mediators can lead to different efficacy and safety profiles, using B cell targeting as example. In addition, we discuss the emerging fie

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Humanized Mice as Preclinical Models in Transplantationtransplantation. We have now entered an exciting era with research on humanized mice driving advances in translational studies and in our understanding of the function of human cells in response to pathogens and cancer as well as the recognition of human allogeneic tissues in vivo. In this chapter w

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Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Theirtypes of organ transplants, is usually not performed before cornea transplantation. With the use of topical steroid immunosuppressants, which are subsequently tailed off to almost zero, most corneal transplants will not be rejected in recipients with low risk of graft rejection. This phenomenon has