Titlebook: Subunit Vaccine Delivery; Camilla Foged,Thomas Rades,Sarah Hook Book 2015 Springer Science+Business Media New York 2015 adjuvants.antigens

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Gels as Vaccine Delivery Systemslivery vehicles are being increasingly translated to the field of subunit vaccine delivery. This chapter will present a summary of gel systems commonly employed to date in the delivery of subunit antigens, categorised according to mechanism of gelation and principal gelling component. Examples of pr

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Parenteral Vaccine Administration: Tried and True well as many of the current vaccines are live or attenuated bacterial or viral preparations, which possess integrated adjuvant properties and their particulate nature enables these vaccines to efficiently drain to secondary lymphatic organs or to activate the innate immune system to carry the vacci

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Nasal Administration of Vaccinesrborne pathogens. For this reason, the nasal mucosa has a dense network of immunocompetent cells which can be utilised for vaccination. The nose has a reasonable inner surface area to allow uptake of a vaccine formulation and the nasal environment offers mild conditions compared to the gastro-intest

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Pulmonary Administration of Subunit Vaccines immune cells through which a systemic as well as a mucosal immune response can be induced. Different types of devices and formulations can be used to administer vaccines to the lungs, each with their own advantages and disadvantages. The choice for a device and formulation is also dependent on the

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ISCOMs as a Vaccine Delivery Systemcterization, and assessment of the mechanisms of action for ISCOMs with examples from our own research, along with addressing the different routes of administration referring to the clinical status of ISCOMs as adjuvants. The future perspectives of using ISCOMs as vaccine adjuvants are presented.