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Titlebook: Subtilisin Enzymes; Practical Protein En Richard Bott,Christian Betzel Book 1996 The Editor(s) (if applicable) and The Author(s), under exc

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书目名称Subtilisin Enzymes
副标题Practical Protein En
编辑Richard Bott,Christian Betzel
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Subtilisin Enzymes; Practical Protein En Richard Bott,Christian Betzel Book 1996 The Editor(s) (if applicable) and The Author(s), under exc
描述Subtilisin is the most extensively studied model system for protein engineering. The primary motivating factor for the interest in subtilisin is the commercial utility of this class of proteases. The subtilisin symposium was the first international meeting to bring together a large number of groups that have focused on the subtilisins and the subtilases-the protein superfamily of subtilisin-like enzymes. The results presented at the symposium are in this way a unique compendium of a broad spectrum of work largely focused on harnessing the potential of site-directed mutagenesis to understand and deliberately alter the function of these enzymes toward a desired end. This sort of protein engineering has been extremely successful in subtilisin, with many such "engineered" enzymes now widely used in commer­ cial enterprises. In this regard the experience derived from subtilisin does represent practical protein engineering. It is becoming clear that subtilisin represents a larger class of enzymes, the subtilases, that include many of the human pro hormone-converting enzymes. As international collabo­ rative efforts to sequence entire genomes continue, we can reasonably expect that additi
出版日期Book 1996
关键词enzyme; enzymes; fungi; genes; protein; protein engineering; system
版次1
doihttps://doi.org/10.1007/978-1-4613-0319-0
isbn_softcover978-1-4613-7995-9
isbn_ebook978-1-4613-0319-0Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

书目名称Subtilisin Enzymes影响因子(影响力)




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Design of Specific Peptide Structures and Subtilisin Enzyme Inhibitors Using α, β-Dehydro-ResiduesThe steric effects caused by dehydro-residues are strong and predictable. They are site specific. They can be used to generate various specific peptide structures. A dehydro-residue adopts only three sets of 6Ψ values: 80, 0°; -60, 140° and -60,-30° and their corresponding enantiomeric structures. I
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Structure and Function of Subtilisin BPN’ as Studied Through Crystallographic Studies on a Series ofo identical subunits, each of molecular weight 1 1,500.. It strongly inhibits a microbial serine proteinase, subtilisin BPN’ (E), forming an E.I. complex of molecular weight 79,000. There are many grounds for believing that the structures of the complexes of serine proteinases with their proteinaceo
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