| 书目名称 | Study on the Cellular Regulation and Function of Lysine Malonylation, Glutarylation and Crotonylatio | | 编辑 | Xiucong Bao | | 视频video | | | 概述 | Nominated as an outstanding Ph.D. thesis by the University of Hong Kong.Reports on important advances in the study of histone posttranslational modifications (PTMs).Introduces applications of the CLAS | | 丛书名称 | Springer Theses | | 图书封面 |  | | 描述 | This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in varioushuman diseases.. | | 出版日期 | Book 2020 | | 关键词 | Epigenetics; Chemical Reporter; Histone Posttranslational Modifications; Chromatin Structure; Protein-pr | | 版次 | 1 | | doi | https://doi.org/10.1007/978-981-15-2509-4 | | isbn_softcover | 978-981-15-2511-7 | | isbn_ebook | 978-981-15-2509-4Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer Nature Singapore Pte Ltd. 2020 |
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发表于 2025-3-21 18:34:04
