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Titlebook: Structure-Activity Relationships of Anti-Tumour Agents; D. N. Reinhoudt,T. A. Connors,K. W. Poll Book 1983 Martinus Nijhoff Publishers, Th

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,Quantitative Structure — Activity Relationship Studies Around Cytotoxic Drugs,ppropriately quantified structural features..These test-data should be obtained from (a) . between chemical substances belonging to (b) . and (c) . in a biological system..In general, toxicological phenomena do not fulfil this requirement since they are not in the least representing a well-defined i
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DTIC: A Springboard to New Antitumour Agents, definitive account of the mode of action of the drug has yet to appear. There are almost as many theories purporting to explain the mode of action of DTIC as there are chemists and biochemists who, ensnared by the apparent deceptive simplicity of the molecule, have responded to the challenge but ab
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the field of cancer, aiming to improve prognosis of the cancer patient. For almost a century, surgery has now been the main treatment modality for the cancer patient. During the past 50 years radiation therapy has developed as a second important modality of treatment. However, neither of the two mod
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,Bioreductive Alkylation — Naturally Occurring Quinones as Potential Candidates,rbohydrate, etc.) to the enone of the methide. This postulate is represented by the sequence of reactions outlined in Scheme 1, ., . → . → . →.. Further comments concerning the details of this proposed mechanism of action follow. 1) Although a two-electron reduction is represented, a one-electron pr
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